This is the first evidence that the expression of vasoactive proteins in mucosa from the gastric antrum of patients with cirrhosis reflects their vascular dysfunction and possibly changes after therapeutic interventions.
In this study, recognition of apnoeas by means of polysomnography (PSG) and nocturnal respiratory sound recordings in patients with obstructive sleep apnoea (OSA) was analyzed and compared. In 45 patients with OSA requiring treatment (AHI> 15/h), concomitant polysomnographic recordings and long term respiratory sound recordings by means of LEOSound were performed. Patients' average age was 58 ± 12 years (mean ± standard deviation), average BMI was 33 ± 7 kg/m. Audio-visual apnoea detection by LEOSound was compared to polysomnographic apnoea detection. Increased artifact rate due to dislocation of microphones led to rejection of 11 out of 45 recordings for detailed analysis. Comparison of apnea detection by audio-visual analysis and polysomnography yielded a median of 164 apneas for LEOSound recordings and 158 apneas for PSG. Median apnoea index (AI) was calculated to be 20/h for respiratory sounds recording and 21/h for PSG. The correlation of apnea indices from acoustic long term registration and PSG was 0.939 (p< 0.001). Acoustic long term registration of primary and secondary respiratory sounds is also capable to recognize apnoeas. Exact differentiation between apnoeas and hypopnoeas is only possible in a limited fashion.
Mit dem Präventionspreis der DGIM wurde Prof. Jonel Trebicka von der Uni Bonn geehrt. Ein von ihm entwickelter Test kann besser vorhersagen, ob die Gabe von Betablockern, die Menschen mit Leberzirrhose vor tödlichen Blutungen aus der Speiseröhre schützen sollen, wegen damit verbundener Risiken sinnvoll ist oder vermieden werden sollte. Der Nachwuchsforscher erhielt dafür im Rahmen des 123. Internistenkongresses den mit 10 000 Euro dotierten Preis der Deutschen Stiftung Innere Medizin (DSIM) und der DGIM.
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