ZusammenfassungDer Blepharospasmus ist eine fokale Dystonie und eine seltene Erkrankung des Gehirns, bei der es zu unwillkürlichen Verkrampfungen der Lidschlussmuskulatur kommt. Die Diagnose wird klinisch gestellt und kann im Zweifel durch elektrophysiologische Untersuchungen bestätigt werden. Die Therapie der Wahl ist die lokale Injektion von Botulinumtoxin, die regelmäßig wiederholt werden muss.
This article aims at drawing attention to the peculiar association of intense exposure to sunlight and subacute development of sensory neuropathy which was seen in 7 psychiatric patients treated with the phenothiazine derivative, perazine. Three patients additionally developed bilateral VII nerve palsy. Symptoms followed a monophasic course with almost complete remission. Routine neurophysiology suggested axonal neuropathy confirmed by sural nerve biopsy in 1 patient. A toxic origin of neuropathy is supposed, possibly induced by phenothiazine photoproducts, which may cause cell damage via lipid peroxidation. 0
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