DAS28-ESR discriminates satisfactorily between groups of patients with active and non-active disease, with no evidence of additional physician-specific factors to explain disease activity status. However, DAS28-ESR is not as good for discriminating remission from non-remission status. There are appreciable probabilities of misclassification error, which make DAS28-ESR inappropriate as a sole guide for treatment decisions.
week 16, EASI-75 at week 2, WP-NRS response at week 16, WP-NRS response at week 4, and WP-NRS response at week 1; and these eight safety outcomes of interest were any treatmentemergent adverse event (TEAE), serious adverse events (SAE), adverse events leading to discontinuation of study drug (AELD), acne, upper respiratory tract infection (URTI), nasopharyngitis, headache, and plasma creatine phosphokinase elevation (PCPE). Random-effects network meta-analysis was conducted
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