In the presence of copper thiocyanate, sodium thiocyanate and the inexpensive, easy-to-use trifluoromethylating reagent Me 3 Si-CF 3 , diazonium salts are smoothly converted into the corresponding aryl trifluoromethyl thioethers. Combined with diazotisation, this convenient and inexpensive method allows the straightforward synthesis of aryl or heteroaryl trifluoromethyl thioethers from the corresponding anilines.
Compared to Pd(II) or Pd(0) catalysts, the Pd(I) dimer permits the double bond migration of a wide range of unsaturated substrates which can be further hydrogenated in the presence of a chiral system to optically active saturated esters.
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