Highlights d TLR2 signaling is sufficient to drive CD4 + T cell-mediated autoimmune inflammation d TLR2 activation drives an inflammatory transcriptional profile in Th17 cells d TLR2 ligation suppresses IPCEF expression in Th17 cells d Enforced IPCEF expression dampens the migratory potential of Th17 cells
Commercially available ruthenium catalyst, Cp*RuCl(COD), was found to be active in catalyzing Bis-Homo-Diels-Alder [2+2+2] cycloaddition reactions between 1,5-cyclooctadiene and various alkynes giving moderate to good yields (35%–92%). The presence of electron donating groups, especially hydroxyl groups, greatly enhanced the reactivity of the alkyne moiety in the cycloaddition. The reaction was also found to be successful even in the presence of bulky substituents on the alkynes.
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