Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts.
Literature on fine-needle aspiration of ovarian transitional cell tumor or Brenner tumors is sparse and mostly confined to isolated case reports of metastatic transitional cell tumors. We undertook a retrospective study of intraoperative imprint cytology of ovarian transitional cell tumors to better define the cytologic features of this uncommon ovarian tumor. Between 2005 and 2012, a total of 19 ovarian transitional cell tumors were recorded in our surgical pathology files, 10 of which had concomitant imprint cytologic material available for review. The 10 patients included in this study ranged in age between 43 and 73 years (mean age: 54 years). Nine neoplasms were histologically benign and one was borderline. Nine cases had satisfactory cytologic material for review. The cytologic features can be summarized as follows: the eight benign tumors showed abundant naked nuclei in the background, small and large clusters of tumor cells, abundant cytoplasm, smooth nuclear membranes, and lack of nuclear pleomorphism and mitoses. Single plasmacytoid cells with dense blue abundant cytoplasm, perinuclear vacuoles, nucleoli, microfollicle formation, nuclear grooves, binucleation/multinucleation, and extracellular eosinophilic material were some of the other features that were appreciated. The cytologic features of the one case of borderline transitional cell tumor were similar to those of the benign tumors except for the presence of rare mitoses, easily identifiable nuclear pleomorphism and irregular nuclear membranes. This study highlights some characteristic cytologic features of benign/borderline transitional cell tumors of the ovary which can be of help in recognizing this uncommon neoplasm.
A 31-year-old woman presented with worsening neck pain for 2 weeks. She was treated for muscle spasms at an urgent care clinic with muscle relaxants and narcotic pain medication, but had no relief of symptoms. On physical examination, she had focal tenderness in the midline at the base of the occiput and resistance to any motion of the neck. Routine laboratory examination was unremarkable. There was no associated history of trauma. Computed tomography (CT) scan showed a large, expansile and destructive mass in the right clivus extending into the right petrous bone with associated right medulla effacement ( Figure 1A). Follow-up with magnetic resonance imaging (MRI) again showed a 5.0 × 3.0 × 3.0-cm expansile, destructive mass in the right clivus and along the right anterolateral margin of the foramen magnum/base of the skull ( Figure 1B).
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