Capillary electrophoresis frontal analysis (CE‐FA) can be used to determine binding affinity of molecular interactions. However, its current data processing method mandate specific requirement on the mobilities of the binding pair in order to obtain accurate binding constants. This work shows that significant errors are resulted when the mobilities of the interacting species do not meet these requirements. Therefore, the applicability of CE‐FA in many real word applications becomes questionable. An electrophoretic mobility‐based correction method is developed in this work based on the flux of each species. A simulation program and a pair of model compounds are used to verify the new equations and evaluate the effectiveness of this method. Ibuprofen and hydroxypropyl‐β‐cyclodextrinare used to demonstrate the differences in the obtained binding constant by CE‐FA when different calculation methods are used, and the results are compared with those obtained by affinity capillary electrophoresis (ACE). The results suggest that CE‐FA, with the mobility‐based correction method, can be a generally applicable method for a much wider range of applications.

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Differences in measured amounts of total petroleum hydrocarbons by GC/FID and NAFCs by HRMS indicate that the two methods provide complementary information about the nature of dissolved organic species in a soil or water leachate samples. NAFC molecule class O S is a possible tracer for LOS seepage. CE/LRMS provides complementary information and is a feasible and practical option for source evaluation of NAFCs in water.

The cover image, by Matthew S. MacLennan et al., is based on the Research Article Characterization of Athabasca Lean Oil Sands and Mixed Surficial Materials: Comparison of Capillary Electrophoresis‐Low Resolution Mass Spectrometry and High‐Resolution Mass Spectrometry, DOI: .

The cover image, by Kevin A. Kovalchik et al., is based on the Research Article Characterization of dicarboxylic naphthenic acid fraction compounds utilizing amide derivatization: proof of concept, DOI: .