Past river classifications use incommensurate typologies at each spatial scale and do not capture the pivotal role of topographic variability at each scale in driving the morphodynamics responsible for evolving hierarchically nested fluvial landforms. This study developed a new way to create geomorphic classifications using metrics diagnostic of individual processes the same way at every spatial scale and spanning a wide range of scales. We tested the approach on flow convergence routing, a geomorphically and ecologically important process with different morphodynamic states of erosion, routing, and deposition depending on the structure of nondimensional topographic variability. Five nondimensional landform types with unique functionality represent this process at any flow; they are nozzle, wide bar, normal channel, constricted pool, and oversized. These landforms are then nested within themselves by considering their longitudinal sequencing at key flows representing geomorphically important stages. A data analysis framework was developed to answer questions about the stage‐dependent spatial structure of topographic variability. Nesting permutations constrain and reveal how flow convergence routing morphodynamics functions in any river the framework is applied to. The methodology may also be used with other physical and biological datasets to evaluate the extent to which the patterning in that data is influenced by flow convergence routing. Copyright © 2018 John Wiley & Sons, Ltd.

River corridors exhibit landforms nested within landforms repeatedly down spatial scales. In Pasternack et al. (), a new, scale‐independent, hierarchical river classification was developed that uses five landform types to map the domains of a single fluvial process – flow convergence routing – at each of three–five spatial scales. Given those methods, this study investigated the details of how flow convergence routing organizes nested landform sequences. The method involved analyzing landform abundance, sequencing, and hierarchical nesting along the 35 km gravel/cobble lower Yuba River in California. Independent testing of flow convergence routing found that hydraulic patterns at every flow matched the essential predictions from classification, substantiating the process–morphology link. River width and bed elevation sequences exhibit large, nonrandom, and linked oscillations structured to preferentially yield wide bars and constricted pools at base flow and bankfull flow. At a flow of 8.44 times bankfull, there is still an abundance of wide bar and constricted pool landforms, but larger topographic drivers also yield an abundance of nozzle and oversized landforms. The nested structure of flow convergence routing landforms reveals that base flow and bankfull landforms are nested together within specific floodprone valley landform types, and these landform types control channel morphodynamics during moderate to large floods. As a result, this study calls into question the prevailing theory that the bankfull channel of a gravel/cobble river is controlled by in‐channel, bankfull, and/or small flood flows. Such flows may initiate sediment transport, but they are too small to control landform organization in a gravel/cobble river with topographic complexity. Copyright © 2018 John Wiley & Sons, Ltd.

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This article examines the state of knowledge about how urban planning can comprehend and address the issues facing cities with extensive residential disinvestment and abandonment. It analyses why planning rarely addresses issues facing the most abandoned areas of cities, except to encourage growth and redevelopment, and how planners can think about or understand the causes of widespread urban abandonment. The article suggests that the principles of efficiency and equity can provide guidance for planners' interventions, and discusses the future of planning in the context of abandonment.

Hereditary peculiarities in individual responses to environmental chemicals are a common occurrence in human populations. Genetic variation in glutathione S-transferase, CYP1A2, N-acetyltransferase, and paraoxonase exemplify the relationship of metabolic variation to individual susceptibility to cancer and other toxicants of environmental origin. Heritable receptor protein variants, a subset of proteins of enormous pharmacogenetic potential that have not thus far been extensively explored from the pharmacogenetic standpoint, are also considered. Examples of interest that are considered include receptor variants associated with retinoic acid resistance in acute promyelocytic leukemia, with paradoxical responses to antiandrogens in prostate cancer, and with retinitis pigmentosa. Additional heritable protein variants of pharmacogenetic interest that result in antibiotic-induced deafness, glucocorticoid-remediable aldosteronism and hypertension, the long-QT syndrome, and beryllium-induced lung disease are also discussed. These traits demonstrate how knowledge of the molecular basis and mechanism of the variant response may contribute to its prevention in sensitive persons as well as to improved therapy for genetically conditioned disorders that arise from environmental chemicals.