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The framework of this chapter is psychosomatological. This represents an attempt to integrate different theoretical approaches, including psychodynamic theories of human development, complex systems theory, psycho-neuro-endocrino-immunology (PNEI), and biosemiotics, in studying the pain-depression-anxiety complex [ 1 ].According to such a paradigm, the human being is an entity that simultaneously and constantly is feeling, thinking, and behaving in both physical and psychologicalexistential sense. Complex System Theory and PNEIAccording to complex system theory, human organism itself can be viewed as a suprasystem, consisting of interrelated subsystems in constant interaction within the environment. This complex web of interactions ( connectivity ) is in action, using

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