Functional status of phagocytes in relation to 6 months' short course chemotherapy of tuberculosis was studied with special reference to antigen-5 (Ag-5) of Mycobacterium tuberculosis. Phagocytic capacity and overall generation of reactive oxygen intermediates (ROI) measured as chemiluminescence (CL) response was studied in peripheral blood monocytes obtained from 20 children with pulmonary tuberculosis (PTb) and was compared with 20, age and sex matched, controls. In untreated children the CL response (mean +/- SD) with latex (0.90 +/- 0.08) and Ag-5 (0.99 +/- 0.11) was found to be severely depressed compared with controls (Latex, 19.2 +/- 5.10; Ag-5, 48.12 +/- 7.10). A significant improvement was seen in response to both the stimulants (Latex, 15.20 +/- 1.50; Ag-5, 28.15 +/- 7.32) after 3 months of therapy and became equal to, or slightly higher than, the values obtained with controls by the end of therapy. This study suggests that newly diagnosed untreated PTb is associated with an in vitro antigen specific compromise of phagocytic capacity and oxidative metabolic burst activity that is gradually and progressively corrected during the course of effective short course chemotherapy. In addition, Ag-5 is a potent stimulator of monocytes/macrophages; its potency being far greater than latex.
Diffuse parenchymal lung diseases (DPLD) encompasses a hetero-geneous group of disorders, characterized by a spectrum of inflammatory and fibrotic changes affecting alveolar walls and air spaces. The onset, rate of progression and duration of symptoms are extremely variable, and presentations range from asymptomatic with long standing radiological changes to an acute onset of breathlessness. MATERIALS AND METHODS: Prospective study conducted on 30 patients admitted in Government general and chest hospital Hyderabad, All patients with clinical features and HRCT diagnostic of Idiopathic pulmonary fibrosis are included in the study. Study was done between February 2013 to December 2014. BAL was done based on ATS guidelines. RESULTS: Out of 30 patients, 19 were females and 11 were males. Out of 30 patients, 21 patients were having neutrophils as predominant cell type in BAL fluid, 6 patients were having lymphocytes as predominant cell type and 2 were having eosinophils and 1 patient was having macrophages as predominant cell type in BAL fluid. In patients with neutrophil predominant BAL fluid, 8 patients found to be having exclusively neutrophils and other cells were within normal limits and 5 were having raised lymphocytes, 5 were having raised eosinophils along with neutrophils and 3 patients were having both lymphocytes and eosinophils along with neutrophils. In patients with lymphocyte predominant BAL fluid, 1 patient is having exclusively raised lymphocytes and 5 patients were having raised neutrophils along with lymphocytes in BAL fluid. 2 patients were having exclusively raised eosinophils in BAL fluid.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.