that forms between CTL and target. However, the molecular machinery involved in the polarization of secretory lysosomes is still largely uncharacterized. In this paper, we investigated the role of Rab7 in the polarization of secretory lysosomes. We show that silencing of Rab7 by RNA interference reduces the ability of CTL to kill targets. GTP-bound Rab7 and Rab interacting lysosomal protein, RILP, interact and both localize to secretory lysosomes in CTL. Over-expression of RILP recruits dynein to the membranes of secretory lysosomes and triggers their movement toward the centrosome. Together, these results suggest that Rab7 may play a role in secretory lysosome movement toward the centrosome by interacting with RILP to recruit the minus-end motor, dynein.
A delegation from the Australian Academy of Technological Sciences and Engineering traveled to Beijing in April 2016 to jointly run a workshop on technology advances in food safety with the Chinese Academy of Engineering. This brief summary from the Australian delegation identifies the pyramid of interlocking issues which must be addressed to deliver food safety. Systems and technology provide the necessary base, on which culture and then trust can be built to facilitate the delivery of food safety now and in the future.
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