The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition Graphical abstract Highlights d Distribution of infant gut resistome is bimodal, mainly driven by E. coli d The infant gut resistome is significantly affected by environmental factors d Low maturity of microbiome associates with high ARG load d A similar asthma-associated gut bacterial composition associates with high ARG load

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