A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.
C-Acylation of Cyclopropanols: Preparation of Functionalized 1,4-Diketones. -This method was deployed as key reaction in total synthesis of (+)-myrmicarin 217 (XXII). -(PARIDA, B. B.; DAS, P. P.; NIOCEL, M.; CHA*, J. K.; Org. Lett. 15 (2013) 7, 1780-1783, http://dx.
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