Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this study, a new mononuclear platinum(II) complex
1
was prepared that is capable of driving the crystallization of the DNA oligomer 5′‐d(CGTACG)‐3′ specifically into a 4WJ‐like motif. In the crystal structure of the
1
–CGTACG adduct, the distorted‐square‐planar platinum complex binds to the core of the 4WJ‐like motif through π–π stacking and hydrogen bonding, without forming any platinum–nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.
are supramolecular DNAa ssemblies comprising four interacting DNAs trands that in biology are involved in DNA-damage repair.I nt his study,anew mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNAoligomer 5'-d(CGTACG)-3' specifically into a4WJ-like motif.I nt he crystal structure of the 1-CGTACGa dduct, the distorted-square-planar platinum complex binds to the core of the 4WJ-like motif through p-p stacking and hydrogen bonding,without forming any platinum-nitrogen coordination bonds.O ur observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNAs uperstructure.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.org/10.
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