Viruses continued to emerge and bring challenges to the global public health system with emerging viruses with respiratory contagion. Previous studies have shown that the increased incidence of certain viral respiratory infections, including influenza and coronavirus, is associated with low levels of Vitamin D, zinc and iron. Elements such as iron, zinc and Vitamin D influence adaptive immunity by inhibiting the proliferation of B cells with differentiation and secretion of immunoglobulins that will supply the proliferation of T cells and this will result in a more pro-inflammatory response change.

In recent years, new viruses have emerged and caused pandemics in several countries, making it a global health problem through respiratory infection. This study aims to demonstrate through an analysis of evidence, that vitamin D supplementation in cases of hypovitaminosis D in risk groups induces an increase changes in the immune system due to worsening and, thus, the body becomes conducive to development viral diseases like COVID-19. Therefore, methodological techniques were used in meta-analysis and systematic reviews parallel to the FINER strategy in the selection of the included studies to be used in the construction of this critical analysis. In this study, 05 articles were selected for inclusion in this critical analysis. Vitamin D plays an immune protective role in the body, decreasing the risk of complications in COVID-19. The decrease in immune cells and cytokines can be used as a biomarker in the process of worsening COVID-19.

Vitamin D is condensed by the complex human body from exposure to sunlight. However it can be absorbed through the consumption of foods such as fish liver oil, high fat fish such as (salmon), mushrooms, egg yolk and liver. The present study aimed to describe a case study of gestation with vitamin D supplementation in a patient with multiple sclerosis. The methodology used in this study was the case report. This study provided reports which may serve as evidence on the effect of vitamin D supplementation alone on the gestational process response.

Goals: To verify whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in the process of infectious reduction in hospitalized children. Data source: This study is a systematic review and meta-analysis of randomized controlled trials, published between 2011 and the first quarter of 2019, in the Cochrane Library, Medline, US National Library of Medicine and the National Institute of Health (PubMed), Literature databases. Latin American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science. The studies were scored by the Down and Black scale associated with the quality assessment method according to the Cochrane criteria (RCT). Summary of the data: Of the 1475 studies, 09 were included. There is a direct relationship between Vitamin D level and mortality rate in hospitalized children with infections. Conclusion: This study highlighted that the vitamin D deficiency in children under serum analysis during hospitalization triggers severe immunological changes.

Multiple sclerosis (MS) is a chronic complex neurodegenerative disease. A systematic review and meta-analysis were conducted on observational studies and analytics on impact of Vitamin D supplementation in patients with Multiple Sclerosis. In our research, a total of 457 articles were selected and identified for analysis. This systematic review article and meta-analysis, which included evidence from randomized controlled trials conducted with patients with multiple sclerosis, revealed that Vitamin D3 supplementation is effective as an option associated with the treatment of this disease, and that it also has a diffuse protective role against various remission outbreaks in the health. Doses (50,000 IU/week) are appropriate to restore neuroimmunological parameters when used within 12 weeks.