Both EA and TENS treatments were effective in reducing OA-induced knee pain. EA had the additional advantage of enhancing the TUGT results as opposed to TENS treatment or no treatment, which did not produce such corollary effect.
Greater improvements in memory and depressive symptoms for the MM group were revealed in the univariate analysis and pairwise comparisons. The effects on memory could last for at least six weeks post-intervention. However, a mixed multivariate analysis of variance (MANOVA) analysis indicated that there were no significant interactions of group by time effect Conclusion: The findings revealed that the MM intervention may be useful for enhancing the cognitive functions of people with dementia. However, there is insufficient evidence to show that the effects of the MM intervention on outcome variables over time significantly different from those observed among the comparison groups.
Objective-This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in Attention-Deficit/Hyperactivity Disorder (ADHD).Method-Eighty two subjects with ADHD aged 6 to 17 participated in a prospective, doubleblind, placebo-controlled, multiple-dose, crossover titration trial of immediate release MPH three times daily. Subjects were assessed on a variety of parent and clinician ratings, and a laboratory math test. Data reduction based on principal components analysis identified statistically derived efficacy and side effect outcomes.Results-ADHD symptom response was predicted by polymorphisms at the serotonin transporter (SLC6A4) intron 2 VNTR (p=.01), with a suggested trend for catechol-Omethyltransferase (COMT) (p=.04). Gene × dose interactions were noted on math test outcomes for the dopamine D4 receptor (DRD4) promoter (p=.008), DRD4 exon 3 VNTR (p=.006), and SLC6A4 promoter insertion/deletion polymorphism (5HTTLPR) (p=.02). Irritability was predicted by COMT (p=.02). Vegetative symptoms were predicted by 5HTTLPR (p=.003). No significance effects were noted for the dopamine transporter (SLC6A3) or synaptosomal-associated protein 25 (SNAP25).
This is a single-blinded randomized controlled trial to compare the relative effectiveness between manual acupuncture (MA) and electro-acupuncture (EA) on the patients with chronic tennis elbow. Twenty patients recruited in the study were first introduced into control group for 2 weeks waiting period. Then, they were randomly assigned into either MA or EA group for acupuncture treatment. The acupuncture points of GB34 and ST38 were used in both treatment groups. In the MA group, the needle was retained for 20 minutes after the Deqi sensation obtained. In the EA group, electrical stimulation with 4 pulses/second frequency was applied and treatment lasted for 20 minutes. After 6 treatments within 2 weeks duration, significant differences were observed between groups favoring the electro-acupuncture in relation to pain relief (Pain visual analogue scale) and pain free hand grip strength (PFG). This study showed that electro-acupuncture is superior to manual acupuncture in treating patients with tennis elbow.
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