No abstract

Alzheimer's disease is the most prevalent cause of dementia in aging people. 7-Methoxytacrine (7-MEOTA) is one of the approved drugs for the treatment of this disease. In the current study, a 7-MEOTA delivery system has been prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL) and its physico-chemical properties were investigated as well. The drug amount loaded in nanocapsules has been estimated 65%. The average particle size of the 7-MEOTA@PCL nanocapsules was around 237 nm with polydispersity index of 0.31 and negative surface charge (-21.2 mV). The prepared nanoparticles are stable upon 40 days storage at 25 °C, without any decomposition. The morphological analysis of the 7-MEOTA@PCL nanoparticles indicated that the nanoparticles are spherical, and free of any aggregation. In vitro release experiments revealed controlled release of the 7-MEOTA from the polycaprolactone nanocapsules. Application of the Korsmeyer-Peppas model to the release kinetics data showed that the release of the drug was by diffusion Fick's law.

Alzheimer’s disease is the most prevalent cause of dementia in aging people. 7-Methoxytacrine (7-MEOTA) is one of the approved drugs for the treatment of this disease. In the current study, a 7-MEOTA delivery system has been prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL) and its physico-chemical properties were investigated as well. The drug amount loaded in nanocapsules has been estimated 65%. The average particle size of the 7-MEOTA@PCL nanocapsules was around 237 nm with polydispersity index of 0.31 and negative surface charge (-21.2 mV). The prepared nanoparticles are stable upon 40 days storage at 25 °C, without any decomposition. The morphological analysis of the 7-MEOTA@PCL nanoparticles indicated that the nanoparticles are spherical, and free of any aggregation. In vitro release experiments revealed controlled release of the 7-MEOTA from the polycaprolactone nanocapsules. Application of the Korsmeyer-Peppas model to the release kinetics data showed that the release of the drug was by diffusion Fick’s law.