Background Thalassemia major is one of the most inherited disorders in the Middle East; it has many complications related to iron overload and hepatitis viral transmission; complication of iron overload has destructing effect on many organ systems including liver; heart; pancreas; and lung. In the lung lead to pulmonary arterial hypertension which is defined as pulmonary artery systolic pressure ≥25mmHg during rest. Objectives To detect the prevalence of pulmonary hypertension in patients with thalassemia major and how supportive measures affecting outcome of it. Patients and Methods A cross sectional study undertaken in Shaheid Hemn Teaching hospital, center for internal medicine diseases with collaboration of thalassemia center inside the hospital; 100 thalassemia major patients who are diagnosed previously by hemoglobin electrophoresis without any other comorbidity taken as a sample and echocardiography done using Phillips CX50 machine of 2009 model; the data then collected and using SPSS v23 for analyzing data. Results Study show 53% of thalassemia major has evidence of increased pulmonary artery pressure and only 1% has clinically significant pressure; splenectomy show high risk factor for occurrence of pulmonary hypertension but other supportive measures has no obstacle effect in its occurrence. Conclusion Most thalassemia major patients have evidence of pulmonary hypertension at least mild one; and putting splenectomy as a last line of managing them is recommended.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.