BackgroundAberrant expression of CD70 in several malignancies is potentially associated with poor patient prognosis and could serve as a therapeutic target. However, the clinical relevance of CD70 expression in pancreatic cancer has not been thoroughly explored.MethodsWe evaluated CD70 expression in 166 surgical specimens obtained from human patients with pancreatic cancer. We analyzed the function of CD70 in proliferation and migration using pancreatic cancer cell lines with silenced CD70 expression.ResultsCD70 expression was positively stained in 42 patients (25%). In the whole cohort, high CD70 expression was not associated with overall survival (OS: 33.1 vs. 40.8 months, P = 0.256), although it was significantly associated with inferior OS in a population of patients that completed adjuvant chemotherapy (P = 0.027). Moreover, the incidence of hematogenous metastasis was significantly higher in patients with high CD70 expression than in those with low CD70 expression (P = 0.020). This finding was also statistically significant in multivariate analyses (P = 0.001). In vitro experiments demonstrated that CD70 expression contributed to cancer cell proliferation independently of gemcitabine treatment as well as cell migration. Furthermore, real-time polymerase chain reaction analysis of frozen surgical tissues showed a correlation between the expression of CD70 and mesenchymal markers.ConclusionsCD70 expression in pancreatic cancer might be involved in hematogenous metastasis. Furthermore, our results imply that CD70 overexpression can serve as a novel prognostic factor and a potential therapeutic target in patients who have completed adjuvant chemotherapy.
Background The impact of the surgical margin (SM) on long-term survival remains controversial. This study retrospectively investigated the impact of the SM on prognosis and recurrence of intrahepatic cholangiocarcinoma (ICC) and evaluated the optimal margin width. Methods We reviewed the medical records of 58 ICC patients who underwent macroscopically curative surgery. Results The patients were classified into five categories according to the SM; R1, 0 to < 1 mm, 1 to < 5 mm, 5 to < 10 mm, and ≥ 10 mm. The prognosis tended to be different for SM < 1 mm or SM ≥ 1 mm, therefore, the cut-off value was set at 1 mm. Thirty-three (56.9%) patients had an SM ≥ 1 mm, and 25 (43.1%) had an SM < 1 mm. The multivariate analysis identified SM < 1 mm (p = 0.027) and microvascular invasion (p = 0.026) as independent prognostic factors of overall survival. After the propensity score-matching based on tumor-related factors, the overall survival and relapse-free survival rates of the SM < 1 mm group were significantly lower than those of the SM ≥ 1 mm group (p = 0.013 and p = 0.025, respectively). Peritoneal dissemination was significantly increased in the SM < 1 mm group than in the SM ≥ 1 mm group (p = 0.007). The post-recurrence survival rate of the SM < 1 mm group was significantly lower than that of the SM ≥ 1 mm group (p = 0.012). Conclusions This study suggests that an SM of at least 1 mm should be achieved during ICC resection. An SM < 1 mm may indicate a higher risk of peritoneal dissemination.
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