Several macrocyclic lactones of the trichothecene class of compounds exhibit significant anticancer activity.' A common structural subunit in each of these lactones is the sesquiterpene verrucarol(1). Anguidin (2), a more highly oxygenated analogue, also shows inhibitory activity against several cancers., Calonectrin (3), considered to be the biogenetic precursor to verru~arol,~ has recently been isolated.

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Dehydroabietic acid (1) was converted into 14 and 20 having the steroidal skeleton, by the use of its isopropyl group for the formation of the steroidal d-ring.

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