In all LEMS studies, SFEMG was abnormal on the first evaluation. The mean MCD correlated well with clinical and electrophysiological disease severity on the repetitive nerve stimulation test.
BackgroundLambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC). Three cases of seronegative myasthenia gravis (MG) and SCLC were previously reported.Case ReportA 65-year-old man developed a severe progressive respiratory failure with clinical features of MG. Tests showed a decremental response in the repetitive nerve stimulation test, abnormal single-fiber electromyography, and positive acetylcholine receptor antibody. SCLC was confirmed by the lung biopsy.ConclusionsThis case represents the first case of seropositive MG and SCLC.
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