Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir

Yagi, Takuya; Hattori, Hidenori; Ohira, Masayuki; Nakamichi, Kazuo; Takayama-Ito, Mutsuyo; Saijo, Masayuki; Shimizu, Toshihiko; Ito, Daisuke; Takahashi, Katsumi; Suzuki, Noriyuki

doi:10.1016/j.clineuro.2009.10.005

Cited by 21 publications

(19 citation statements)

References 16 publications

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“…Until now, only few cases on the coincidence of PML and sarcoidosis have been reported 5, 6, 7, 8. Our case series adds new important observations and thus helps raising the level of alertness to this rare brain infection in these conditions.…”

Section: Discussionmentioning

confidence: 53%

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Gamperl

Enzinger

Pichler

et al. 2018

Clinical Case Reports

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Section: Discussionmentioning

confidence: 53%

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Gamperl

Enzinger

Pichler

et al. 2018

Clinical Case Reports

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“…There have been numerous small trials with various experimental treatments, including cytarabine, cidofivir, topotecan, and mefloquine, all with varying results. There is no clear evidence, however, that any of these treatments are commonly effective in reversing the course of disease [1,3,5,7-11]. These treatment options were not considered for our patient.…”

Section: Discussionmentioning

confidence: 99%

Progressive Multifocal Leukoencephalopathy as the First Manifestation of Occult Sarcoidosis

2013

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A patient presented with mental status changes over several weeks. Imaging indicated several areas of hyperintensity in the white matter of the temporal and parieto-occipital lobes. Brain biopsy and CSF analysis led to the diagnosis of progressive multifocal leukoencephalopathy (PML). Though this patient had no clinical evidence of immune suppression, autopsy later indicated the presence of undiagnosed systemic sarcoidosis, which has been associated with PML.

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“…Recently, the case report that shows the effectiveness of cidofovir for non-HIV-related PML has been reported [16]. However, no routinely recommended therapy has been established for PML or JCV infection.…”

Section: Discussionmentioning

confidence: 97%

Progressive multifocal leukoencephalopathy in a patient with multiple myeloma

et al. 2010

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Progressive multifocal leukoencephalopathy (PML) is a neurological disease that affects immunodeficient patients. We describe here a case of 64-year-old man with IgD type multiple myeloma (MM) who developed progressive neurological symptoms. T(2)-weighted magnetic resonance imaging of the brain showed a hyperintense non-enhancing lesion in the left frontal lobe, and analysis of the cerebrospinal fluid by polymerase chain reaction revealed the presence of John Cunningham virus (JCV) DNA. Histopathological analysis of the autopsy brain specimen with in situ hybridization assay revealed the presence of JCV DNA in the nuclei of oligodendroglia. PML in a patient with MM is rare. However, this case report suggests that PML should be suspected and relevant diagnostic examinations should be performed when MM patients present with neurological symptoms.

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Progressive multifocal leukoencephalopathy developed in incomplete Heerfordt syndrome, a rare manifestation of sarcoidosis, without steroid therapy responding to cidofovir

Cited by 21 publications

References 16 publications

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Can pulmonary sarcoidosis trigger a progressive multifocal leukoencephalopathy? Considerations from a case series and a review of literature

Progressive Multifocal Leukoencephalopathy as the First Manifestation of Occult Sarcoidosis

Progressive multifocal leukoencephalopathy in a patient with multiple myeloma

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