We propose the Hyper-Kamiokande (Hyper-K) detector as a next generation underground water Cherenkov detector. It will serve as a far detector of a long baseline neutrino oscillation experiment envisioned for the upgraded J-PARC, and as a detector capable of observing -far beyond the sensitivity of the Super-Kamiokande (Super-K) detector -proton decays, atmospheric neutrinos, and neutrinos from astronomical origins. The baseline design of Hyper-K is based on the highly successful Super-K, taking full advantage of a well-proven technology.Hyper-K consists of two cylindrical tanks lying side-by-side, the outer dimensions of each tank being 48 (W) × 54 (H) × 250 (L) m 3 . The total (fiducial) mass of the detector is 0.99 (0.56) million metric tons, which is about 20 (25) times larger than that of Super-K. A proposed location for Hyper-K is about 8 km south of Super-K (and 295 km away from J-PARC) at an underground depth of 1,750 meters water equivalent (m.w.e.). The inner detector region of the Hyper-K detector is viewed by 99,000 20-inch PMTs, corresponding to the PMT density of 20% photo-cathode coverage (one half of that of Super-K).Hyper-K presents unprecedented potential for precision measurements of neutrino oscillation parameters and discovery reach for CP violation in the lepton sector. With a total exposure of 5 years (one year being equal to 10 7 sec) to a 2.5-degree off-axis neutrino beam produced by the 1.66 MW J-PARC proton synchrotron, it is expected that the CP phase δ can be determined to better than 18 degrees for all possible values of δ and CP violation can be established with a statistical significance of 3σ for 74% of the δ parameter space if sin 2 2θ 13 > 0.03 and the mass hierarchy is known. If sin 2 2θ 13 is as large as 0.1 the mass hierarchy can be determined with more than 3σ statistical significance for 46% of the δ parameter space. In addition, a high statistics data sample of atmospheric neutrinos will allow us to extract the information on the mass hierarchy and the octant of θ 23 . With a full 10 year duration of data taking, the significance for the mass hierarchy determination is expected to reach 3σ or greater if sin 2 θ 23 > 0.4.Hyper-K can extend the sensitivity to nucleon decays beyond what was achieved by Super-K by an order of magnitude or more. The sensitivities to the partial lifetime of protons for the decay modes of p → e + π 0 and p → νK + are expected to exceed 1 × 10 35 years and 2 × 10 34 years, respectively. This is the only known, realistic detector option capable of reaching such a sensitivity for the p → e + π 0 mode.The scope of studies at Hyper-K also covers high precision measurements of solar neutrinos, observation of both supernova burst neutrinos and supernova relic neutrinos, dark matter searches, and possible detection of solar flare neutrinos. The prospects for neutrino geophysics using Hyper-K are also mentioned.
This corrects the article DOI: 10.1103/PhysRevLett.117.082503.
Hyper-Kamiokande will be a next generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of CP asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams.In this document, the physics potential of a long baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis has been updated from the previous Letter of Intent [K. Abe et al., arXiv:1109.3262 [hepex]], based on the experience gained from the ongoing T2K experiment. With a total exposure of 7.5 MW × 10 7 sec integrated proton beam power (corresponding to 1.56 × 10 22 protons on target with a 30 GeV proton beam) to a 2.5-degree off-axis neutrino beam produced by the J-PARC proton synchrotron, it is expected that the CP phase δCP can be determined to better than 19 degrees for all possible values of δCP , and CP violation can be established with a statistical significance of more than 3 σ (5 σ) for 76% (58%) of the δCP parameter space.
Background. Central sensitization (CS) and psychological factors are associated with pain intensity; however, the mediating role of CS on the relation between psychological factors and pain intensity remains unclear. Objectives. We performed mediation analysis to investigate how CS mediates relation between psychological factors and pain intensity. Methods. Twenty patients with musculoskeletal pain were included in this cross-sectional study. Central sensitization inventory (CSI), one pain intensity-related outcome measure (Short-Form McGill Pain Questionnaire 2 (SFMPQ2)), and three psychological outcome measures (Hospital Anxiety and Depression Scale (HADS), Pain Catastrophizing Scale-4 (PCS), and Tampa Scale for Kinesiophobia-11 (TSK)) of all participants were assessed. The mediation analysis with a bootstrap sampling procedure was used to assess the indirect effects. The level of significance was set at 5%. Results. Mediation analysis showed that the HADS-anxiety, HADS-depression, and PCS had significant indirect effects on the pain ratings of CSI. Additionally, the direct effect was significant only for PCS. Conclusions. The relationship among anxiety symptoms, depression symptoms, and pain intensity was completely mediated by CS. Furthermore, the relationship between catastrophic thinking and pain intensity was partially mediated by CS. Our findings suggest that CS mediates relation between psychological factors and pain intensity, and CS-focused intervention may be important.
The central sensitization inventory (CSI) evaluates the central sensitization (CS)-related symptoms associated with increased pain sensitivity. However, the CSI includes items that are not directly related to pain. In this study, 146 patients with pain were classified into subgroups by k-means cluster analysis based on the short form of the central sensitization inventory (CSI9) and pain scores. In addition, inter-group and multiple comparisons were performed to examine the characteristics of each group. As a result of this study, there were three subgroups (clusters 1, 2, and 3) in which the CSI9 and pain intensity were both low, moderate, and high, and one subgroup (cluster 4) in which only CSI9 was high and pain intensity was low. Two subgroups with high CSI9 scores but contrasting pain intensities (clusters 3 and 4) were extracted; the pattern of CS-related symptoms in these two groups was very similar, with no differences in most of the non-pain factors. It is necessary to consider these points when interpreting the clinical condition of a patient with pain when using the assessment of CS-related symptoms.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.