The TD97 strain vaccine virus was prepared from the Tanabe strain measles virus by low-temperature passages in primary cell cultures and ultraviolet (UV) mutagenesis. The TD97 strain exhibited the following characteristics: highly temperature sensitive, neither multiplying nor forming any plaques at 40 degrees C in Vero cells; genetically stable, maintaining high temperature sensitivity after ten successive passages in CE cells at 30 degrees C or 35 degrees C; and M proteins of this virus about 1 KD slower in mobility in SDS-PAGE than that of the Tanabe strain. The TD97 strain was further confirmed to be attenuated by an inoculation test into primate brain. In field trials, 752 healthy children were inoculated with a live virus vaccine prepared with this strain, and the following results were obtained: the seroconversion rate was 97% (517/533), and the average HI antibody titer was 2(5.2). An antibody-increasing effect was also observed in children who were initially seropositive. In children who seroconverted, the rates of fever were 15.7% (55/351) for 37.5 degrees C or higher and 4.0% (14/351) for 39 degrees C or higher. The rash rate was 7.7% (27/351), and the incidence of local reaction was 5.4% (19/351). The TD97 strain is thus considered to be suitable in use for an attenuated measles vaccine.
We report the major and trace element chemistry and Sr and Nd isotopic composition of basaltic rocks from the Quaternary Tateshina volcano, central Japan, and model the composition of these rocks in terms of the partial melting and melt -solid reactions controlled by the addition of slab -derived fluid and silicate melt to the original wedge mantle beneath the Tateshina area. Tateshina basaltic rocks have a SiO 2 content ranging from 50.06 to 53.28 wt% and a MgO content ranging from 5 to 7 wt%, indicating that these rocks are less fractionated. These rocks have a narrow range of Sr and Nd isotopic compositions ( Nd -Sm/Nd, indicating that Tateshina basaltic rocks have no crustal contamination. The wedge mantle peridotite would have experienced accumulated subduction events, including the addition of subduction components and the extraction of basalt magmas during the Tertiary period. In addition, we have accounted for the mantle motion accompanying slab subduction within the wedge mantle. Thus, we assumed that the mantle wedge before the effects of Quaternary subduction that produced the volcanic rocks of Tateshina volcano could have blended with residual mantle after the extraction of Tertiary basalt magmas with depleted MORB -source mantle (DMM). The model includes partial melting of the blended wedge mantle peridotite metasomatized by aqueous fluid and silicate melt derived from the dehydration of altered oceanic crust (AOC) and partial melting of oceanic sediments, respectively. The trace element and Sr isotope compositions of the basaltic rocks of Tateshina volcano can be reproduced by about 10% melting of the calculated wedge mantle peridotite modified by the addition of 0.8% -1.0% silicate melt from oceanic sediments and 0.2% -0.8% aqueous fluids from the AOC, respectively.
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