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Vaccination is an important strategy in the protection of aquaculture species from major diseases. However, we still do not have a good understanding of the mechanisms underlying vaccine-induced disease resistance. This is further complicated by the presence of several lymphoid organs that play different roles when mounting an immune response. In this study, we attempt to elucidate some of these mechanisms using a microarray-based approach. Asian seabass (Lates calcarifer) were vaccinated against Streptococcus iniae and the transcriptomic changes within the spleen and head kidney at one and seven days post-vaccination were profiled. We subsequently challenged the seabass at three weeks post-vaccination with live S. iniae and similarly profiled the transcriptomes of the two organs after the challenge. We found that vaccination induced an early, but transient transcriptomic change in the spleens and a delayed response in the head kidneys, which became more similar to one another compared to un-vaccinated ones. When challenged with the pathogen, the spleen, but not the head kidneys, responded transcriptomically at 25–29 hours post-challenge. A unique set of genes, in particular those involved in the activation of NF-κB signaling, was up-regulated in the vaccinated spleens upon pathogen challenge but not in the un-vaccinated spleens. A semi-quantitative PCR detection of S. iniae using metagenomic DNA extracted from the water containing the seabass also revealed that vaccination resulted in reduction of pathogen shedding. This result indicated that vaccination not only led to a successful immune defense against the infection, but also reduced the chances for horizontal transmission of the pathogen. In conclusion, we have provided a transcriptomic analysis of how the teleost spleen and head kidneys responded to vaccination and subsequent infection. The different responses from the two organs are suggestive of their unique roles in establishing a vaccine-induced disease resistance.
We have proposed a method for controlling the vortex chirality in a squared permalloy dot by using the circular Oersted field locally induced by flowing a DC current across a small Py/Cu junctions. The reliability of the chirality control has been evaluated by measuring the nonlocal spin valve signal. The desired vortex chirality has been obtained when the injecting DC current has a moderate magnitude. However, the large DC current is found to reduce the control reliability. Another possibility for controlling the vortex structure using the large DC current injection was also discussed.
A "performance gap" arises when the actual value of building energy consumption during the operational phase deviates from the value predicted using simulation during the design phase. One cause of this performance gap is that operation is not ideal, as assumed in the simulation, and the control of the heating, ventilating, and air conditioning (HVAC) system is not optimized. These problems occur because the operator has not been trained sufficiently and/or the building automation system is not working as intended by the developer. Both problems are fundamentally caused by the fact that the quality of building operation cannot be quantitatively evaluated by comparison with other buildings because a building is a heterogenous, single-item product. To address the performance gap problem, we developed a method for quantitatively evaluating building operation using a precise simulation based on a thermal environment emulator. The emulator software was developed using the BACnet protocol as an interface to the real world and includes an occupant behavior model to enable the assessment of operation in terms of thermal comfort as well as energy performance. In this paper, we report on the program and network structure of the proposed emulator. In addition, we show the concrete results of changing the operational control, and we assess changes in energy performance and comfort from the perspective of Pareto efficiency.
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