Background: Activity-regulated cytoskeleton-associated protein (Arc) transcription is activated by BDNF. Results: BDNF activated the Arc proximal promoter, whereas class I histone deacetylases (HDACs) inhibited this activation. Conclusion: Class I HDACs repress BDNF-induced Arc transcription through its serum response element-containing proximal promoter. Significance: Neuronal Arc expression is regulated by chromatin structure, which may lead to long-lasting changes in neuronal functions.
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