Cannulation of the thoracic duct and femoral vein in dogs was performed so that samples could be taken at intervals. Lymph fibrinolytic factors (especially plasminogen activator, plasminogen and antiplasmin) and the influence of urokinase administered intravenously by one shot on thoracic duct lymph fibrinolysis were studied in dogs weighing 10 kg.Results were as follows. Plasminogen activator, plasminogen and antiplasmin are presented in lymph. Levels of plasminogen in thoracic duct lymph were lower than in blood, but there was no significant difference in antiplasmin levels between in blood and lymph. Lymph plasminogen activator levels were variable and changes of lymph fiibrinolytic activity were not definitive after the administration of 120, 000 units of urokinase. Antiplasmin levels, however, reduced transiently in lymph as well as in blood. The highest radio activity in lymph was seen 30 minutes after administration of 125I-labeled urokinase. Administration of urokinase seemed to increase thoracic duct lymphatic flow, but there was no statistical difference.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.