A neutrino burst was observed in the Kamiokande II detector on 23 February 1987, 7:35:35UT (+ 1 min) during a time interval of 13 sec. The signal consisted of eleven electron events of energy 7.5 to 36 MeV, of which the first two point back to the Large Magellanic Cloud with angles 18~18 and 15 + 27

We report an optimized backbone for the rapid development of a highly sensitive intramolecular fluorescence resonance energy transfer (FRET) biosensor, which includes an optimized pair of fluorescent proteins and a long flexible linker ranging from 116 to 244 amino acids in length. With this backbone system, we developed FRET biosensors of PKA, ERK, JNK, EGFR, RSK, S6K, Akt, PKC, Ras, and Rac1.

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