These results indicate that skin barrier function, cutaneous microcirculatory function and autonomic nervous activity are mutually associated in healthy adults.
Skin is the largest organ of the human body. In recent years, concern regarding the cosmetics area has increased, and research studies on anti-aging therapy or cosmetics have been rapidly conducted. Skin cells are not only changing its shape but also its physical properties during the epidermal skin turnover process. Computational simulation can be useful in further understanding the mechanisms of skin formation. We propose a particle model that can handle complex biological phenomena, including cell interactions and is a suitable method for simulating skin formation. The particle model was applied to simulate three-dimensional skin formation accompanied by proliferation and cornification of skin cells. The simulation results represented and reproduced the epidermal skin turnover phenomenon.
Skin capillaries play an important role in material exchange with tissues. It is known that skin capillaries are in the closest position to the epidermis and thus have a strong connection to skin condition. Capillaries can be observed non-invasively from the skin surface, making them important biomarkers for evaluating diseases such as Raynaud's disease, systemic sclerosis, and diabetes. 1-3 Thus, quantitative evaluation of the capillary structure is a useful diagnostic tool not only for evaluating the health of the skin but also for considering therapeutic strategies in clinical settings. 4 Videomicroscopy has been used to acquire capillary structure, as it can easily and non-invasively provide an image. 5,6 However, analysis of the acquired image is often based on the visual evaluation of a diagnostician. In such evaluations, individual differences can be substantial and the amount of time required for analysis can be extensive. Therefore, many methods for automatically analyzing capillaries have been studied. 7-12 However, these techniques are not
Summary Coffee polyphenols (CPPs) derived from coffee beans have beneficial effects on blood pressure and vascular endothelial function. In addition, CPPs suppress ultraviolet light induced erythema. However, the effects of CPPs on dry skin and cutaneous vascular function have not been clarified. We investigated the effects of CPPs on dry skin and the recovery rate (RR) of skin temperature after a cold-stress test as a measure of vascular function in subjects with visible scaliness in a double-blind, placebo-controlled, randomized study. The subjects were divided into two groups, the CPP group and the Placebo group. In the CPP group, the subjects ingested a beverage containing 297.8 mg CPPs every day for 4 wk. The degree of skin dryness was assessed quantitatively using a Visioscan to evaluate skin scaliness and smoothness. A subjective evaluation using a visual analog scale (VAS) of skin smoothness was also used. As a result, the scaliness and smoothness of cheek skin was significantly improved after 4 wk in the CPP group compared to the Placebo group. The improvements of the VAS score on 'skin smoothness' and the RR were also observed in the CPP group but the difference was not statistically significant. However, when the CPP group was divided into subgroups of high RR and low RR, the improvement of the RR was significant in the low RR subgroup. In conclusion, our results suggest that CPPs improve skin scaliness and play a role in cutaneous blood flow regulation after cold stress.
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