Over the past several decades, green
chemistry has gained prominence
in chemistry education. However, the development of green chemistry
curricula has not reached all levels of education equally, focusing
mainly on elective and upper division courses. We deliberately focused
our green chemistry curriculum redesign on a high enrollment introductory
general chemistry laboratory course at the University of California,
Berkeley. We developed over 30 new experiments that introduced students
to green chemistry concepts and applications, while maintaining canonical
general chemistry learning goals. The context of the curriculum and
required course assignments encouraged students to use green chemistry
principles to explore and solve real-world problems. After completing
this redesigned course, we hypothesized that students would value
green chemistry and feel more confident in their green chemistry knowledge.
We developed new methods to measure students’ attitudes toward
and understanding of green chemistry as a system instead of isolated
reactions or processes. These assessments allowed us to better understand
both the progression and limitations in student green chemistry and
systems-thinking. Since over 2000 students complete the laboratory
course each year, we used a combination of fixed response items and
free response items from online surveys and in-class assignments and
exams. This approach allowed efficient assessment of thousands of
students, while still gaining valuable and nuanced views of student
understanding and attitudes. These assessments indicated that the
new general chemistry laboratory curriculum succeeded in providing
an environment in which students learned green chemistry concepts
and realized that chemistry has connections to their future courses
and professions.
A new class of organocatalyst has been developed that incorporates a sulfinyl group as a urea or thiourea substituent. The sulfinyl group serves to simultaneously acidify the urea and provide asymmetric induction in hydrogen-bond-catalyzed reactions. The utility of this new catalyst structure is demonstrated by the high selectivity provided in the aza-Henry reaction not only for aromatic N-Boc imine substrates but also for aliphatic imines for which enantioselective H-bonding catalysis has not previously been demonstrated.
In this undergraduate analytical chemistry experiment, students quantitatively assess the antibacterial activity of essential oils found in thyme leaves (Thymus vulgaris) in an authentic, research-like environment. This multiweek experiment aims to instill green chemistry principles as intrinsic to chemical problem solving. Students progress through various techniques including extraction, chromatography (TLC and HPLC), culturing bacteria, and disk diffusion via a process of guided exploration that emphasizes green experimental design. Approximately 600 undergraduate students carried out the experiment and self-reported substantial learning gains.
The highly enantioselective addition of thioacetic acid to nitroalkenes using a new sulfinyl urea organocatalyst is described. The addition of thioacetic acid proceeds in high yields and enantioselectivities for a variety of aromatic and aliphatic nitroalkene substrates. This new method is useful for preparing chiral 1,2-aminothiol derivatives, as demonstrated by the first enantioselective synthesis of the clinically used antifungal drug sulconazole.
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