No abstract
The QT interval on the electrocardiogram (ECG) represents the total duration of depolarization and repolarization of the ventricles, its lengthening is associated with rhythm disturbances and increased mortality. QT interval prolongation occurs in approximately 26% of type 2 diabetics. The objective of this study was to assess the prevalence and risk factors of QTc prolongation in patients with type 2 diabetes in a 3-day cross-sectional study conducted at the Department of Endocrinology and Diabetology, Mohammed VI University Hospital, Marrakech, including volunteer type 2 diabetes patients admitted out of emergency. The QT interval was measured manually on ECG tracings. QTc was calculated using Bazett's formula, a QTc interval at the ECG > 440 ms for men and women was considered pathological. Demographic and biological data were also collected. Potential risk factors for prolonged QTc interval were evaluated. Results: We included 126 patients. The mean age of the patients was 57.59 years. The mean duration of diabetes progression was 8.26 years. Mean glycated hemoglobin (HbA1c) was 8.04%, 5.55% were smokers, 2.38% were on diuretics and mean QTc was 432.65 ms. The prevalence of prolonged QTc interval in our patients was 27.77% (21.42% of women and 6.35% of men (p=0.645). Smoking (p=0.025), diuretics (p=0.046) and duration of diabetes (p=0.02) were the significant risk factors in our study.
Introduction: Autonomously hyperfunctioning thyroid nodules, also known as "hot nodules", are defined by increased uptake of radiotracers compared to the surrounding thyroid parenchyma on scintigraphy. It has been believed that hot nodules have a low rate of malignancy, while an increasing number of thyroid carcinoma cases are being diagnosed in patients with hyperthyroidism. Case Presentation: A. J, a 50-year-old patient. She presented with signs of hyperthyroidism. Laboratory tests showed peripheral hyperthyroidism with an inhibited TSH of 0.03 μIU/ml and T4L of 37 pmol/L. The scintigraphy revealed a focus of hyper fixation almost completely affecting the right lobe which corresponded to a hot nodule most likely pre-extincted in the remaining parenchyma. The patient was initiated on synthetic antithyroid medication and, after achieving euthyroidism, she was referred to surgery. Right loboishmectomy was performed. The histological study revealed a 0.5 cm intralobular non-encapsulated microcarcinoma papillary on a background of thyroid dystrophy. Discussion: The initial evaluation of a thyroid nodule begins is the measurement of serum TSH and the performance of a thyroid ultrasound, followed by a thyroid radionuclide scan if the TSH is subnormal. Malignant nodules are usually non-functioning. The prevalence of malignancy associated with a hot nodule range between 1-10.3%. In many cases, thyroid cancer is not known preoperatively but is found incidentally during the postoperative histological examination of the thyroid. Most of these malignancies were of papillary carcinoma and less often follicular or Hurthle histological types, and they are small in size, and the majority are microcarcinomas. Conclusion: Further evaluation and characterization of the association between a hot thyroid nodule and malignancy are needed. In the case of our patient, the discovery of papillary carcinoma was incidental and was made during the postoperative histological examination .......
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.