Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA1C), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured. All statistical analysis was performed with SPSS 16.0. Results: There was a positive correlation between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant difference of serum irisin level between patients with normal and abnormal FBS too. Conclusion: In this study we found, irisin concentration was increased with age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus further research is needed to provide inclusive understanding of irisin associated physiological effects and possible implications in clinical conditions.
Introduction: Type 2 diabetes has become a chronic worldwide epidemic with advancing complications and has caused many premature deaths. Its global prevalence is about 9.7%, with 92.4 million suffering from the disease. Vitamin D level has been recently considered as an adjustable risk factor of cardiovascular diseases in individuals with type 2 diabetes. Objectives: The aim of the current study is to investigate the frequency of vitamin D deficiency and the relationship between vitamin D serum levels and age in type 2 diabetes patients. Patients and Methods:In this descriptive-analytic study, 101 type 2 diabetes patients of Imam Ali clinic in Shahrekord were investigated. Serum vitamin D levels of the participants were measured by DRG (USA) Elisa kits. The results were analyzed using SPSS software with a 95% confidence level. Results: Of 101 studied patients, 32 were male and 69 were female. The average age of the subjects was 61.25 ± 11.75 years. The average age of the males was 63.09 ± 11.15 years and the average age of the females was 60.39 ± 12 years. Around 72 subjects were vitamin D deficient. No significant difference of vitamin D levels between males and females (P = 0.985) was detected. Serum vitamin D levels of type 2 diabetes patients were significantly positive correlated with their ages (r = 0.282, P = 0.004). Conclusion:In the present study the prevalence of vitamin D deficiency in type 2 diabetes patients was 71.3 %. We found a positive significant relationship between the vitamin D level and age. It is possible that ageing process is not one of the causes of vitamin D deficiency.
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