Biochemical and histological evaluations of the effects of the iron chelator desferrioxamine on the nephrotoxicity induced by cisplatin in normal rats were carried out. A single dose of cisplatin (7.5 mg/kg, intravenously) caused nephrotoxicity that manifested biochemically as an elevation of blood urea nitrogen, serum creatinine and an increase in the kidney weight as a percent of body weight. Moreover, severe decreases in serum calcium and albumin were observed. Histopathological examination of kidney tissue revealed tubular necrosis with sloughing of tubular epithelium. Desferrioxamine treatment (250 mg/kg, intraperitoneally) 30 min before cisplatin administration does not protect the kidney from the damaging effects of cisplatin. A greater increase in blood urea nitrogen, serum creatinine and kidney weight was observed with significant tubular necrosis and a mild lymphocytic infiltrate. Desferrioxamine pretreatment decreased the lipid peroxidation induced by cisplatin but at the same time increased nonprotein sulfhydryl (-SH) concentrations in the kidney tissue. The findings of this study suggest that lipid peroxidation is not the main cause of cisplatin-induced nephrotoxicity and that desferrioxamine which was useful for prevention of cardiac and hematological damage induced by doxorubicin, aggravated the cisplatin-induced nephrotoxicity. More investigations are needed to establish a definite assessment of its selectivity.
Aim: Renal replacement therapy is best possible treatment for end stage renal failure, but current research suggestive of augmented long-term risk in renal function for the donor. Methods:At this time, we evaluate the subjects for the risk of decreased (eGFR) estimated glomerular filtration rate within old 50 giver, who undergo pre-donation assessment and live benefactor nephrectomyamong 2007 and 2015by multiple centers of Pakistan. Results:The mean pursuepoint in time was 8.5 years (0.9–28.2). Inco relational analysis, subject age and status of hypertension (arterial) by thereference line were considerablylinked witha elevatedhazard of unfavorable renal effect, in particular, eGFR <60mL/min/1.73m2 (age/year: hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.04–1.08, (HTN): HR 1.09, 95% CI 1.21–4.0), eGFR <60 mL/min/1.73 m2 and a turn down of _39% from the initial measured line (age: HR 1.07, 95% CI 1.03–1.13,HTN: HR 4.22, 95% CI 1.71–10.35), and, eGFR <45mL/min/1.73m2. Age and HTN HR 2.13, 95% CI1.04–1.21, HR 4.05, 95% CI 1.47–18.15 respectively, Adding together, eGFR levels at occasion of contribution was linked with a lesserhazard of eGFR <60 mL/min and eGFR <40 mL/min. The only significantpredictor for adverse renal outcomes was Age. Conclusion: Arterial hypertension, lower level of eGFR, and age at the time of donation are powerful prognosticating factor for undesirable kidney adverse effects in live renaldonor. Keywords: eGFR (per mL/min/1.73 m2) Estimated glomerular filtration rate, arterial hypertension HTN; ESRD
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