Reaction of cyclohexyl isocyanide with aromatic aldehydes, aniline derivatives and trifluoroacetic anhydride in dichloromethane at room temperature afforded N-[cyclohexylcarbamoyl(aryl)methyl]-2,2,2-trifluoro-N-arylacetamide derivatives in nearly quantitative yields after 10 min. The work-up procedure is very easy and the products are precipitated in ether as pure solids. The structure of one of the products was established by X-ray single crystal analysis.
An improved four-component reaction of isocyanides is described. The reaction between two equivalents of an isocyanide, dialkyl acetylenedicarboxylates and aliphatic carboxylic acids at room temperature leads to 2,5diaminofuran derivatives in good yields.
Four-Component Reaction Between Cyclohexyl Isocyanide, Aromatic Aldehydes, Aromatic Amines and Trifluoroacetic Anhydride. -(ANARY-ABBASINEJAD, M.; ANARAKI-ARDAKANI*, H.; RASEKH, M.; TABATABAEE, M.; NAZARI, A.;
Furan derivatives R 0060 Four-Component Reaction of Isocyanides, Acetylenic Esters, and Carboxylic Acids for the Synthesis of Functionalized 2,5-Diaminofurans. -(ANARY--ABBASINEJAD*, M.; RASEKH, M.; ANARAKI-ARDAKANI, H.; J. Chem. Res. 2009, 5, 271-273; Dep. Chem., Islamic Azad Univ., Yazd, Iran; Eng.) -H. Toeppel 44-112
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