Background:The aim of the present study was to determine the relation between neck circumferences (NC), as an indicator of upper body obesity, with anthropometric and cardio-metabolic factors among the first degree relatives of diabetes patients.Materials and Methods:This cross-sectional study was performed on first degree relatives of diabetes patients (n = 213). Weight, height, waist circumference (WC), hip circumference (HC), systolic blood pressure (SBP), diastolic blood pressure (DBP) and NC were measured. Laboratory data included oral glucose tolerance test (OGTT) results, high density lipoprotein (HDL), low density lipoprotein, triglyceride (TG) and total cholesterol.Results:There was no difference in NC among different results of OGTT in men or women. Factors including weight, body mass index (BMI), WC and HC were strongly associated with NC in both genders (r = 0.420-0.711). NC was weakly associated with SBP in women (r = 0.195) and moderately with DBP in men (r = 0.314). Regarding lipid profile, HDL and TG were associated with NC only in women (r = −0.268-0.325).Conclusions:NC has a significant correlation with gender and anthropometric variables including BMI, weight and waist and HCs in both men and women but it does not differ significantly in patients with different status in OGTT.
Introduction: Failure to respond to the chemotherapy and relapse occurrence is considerably high in acute leukemia as one of the most common hematologic malignancies requiring emergent efficacious well-tolerated salvage therapy. However, varieties of regimens have been investigated, since the best approach with an optimal response is a question. Objectives: In our study, we aimed to compare the efficacy of FLANG (fludarabine, cytosine arabinoside, mitoxantrone and G-CSF) versus mitoxantrone and etoposide for the treatment of refractory/relapsed acute leukemia. Patients and Methods: In this retrospective cohort study, 45 patients with acute leukemia were randomly divided into two groups of salvage therapy with FLANG (n=23) and mitoxantrone and etoposide (n=22). The patients were followed for five years. Progression-free survival, response to the treatment, chemotherapy-induced toxicity based on Criteria for Adverse Effects version 4 (CTCAE-4), and mortality were compared between the groups. Besides, to estimate the survival Kaplan-Meier curve and Cox regression were used. Results: Comparison of the two regimens revealed insignificant differences in terms of response rate (P=0.87), chemotherapy-induced toxicity (P=0.22) and mortality rate (P=0.26) and etiology of mortality (P=0.98). The median progression-free survival following FALNG and the latter regimen was four months (95% CI: 3.183, 4.862) versus three months (95% CI: 1.777, 4.223; P=0.38 ), respectively. Conclusion: Based on this study, the two salvage regimens of mitoxantrone plus etoposide and FLANG were similar in terms of complete remission, progression-free survival, and toxicity for the cases with refractory/ relapsed acute leukemia. Trial Registration: This study has been registered in the Iranian Registry of Clinical Trials and obtained code IRCT20190618043939N1 (https://en.irct.ir/trial/40272, Ethical code# IR.MUI.MED.REC.1398.586).
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