Excess dietary fat, and associated bile acids, can impair intestinal barrier integrity, produce intestinal or systemic inflammation and promote tumorigenesis. Dietary polyphenols in foods such as berries display antioxidant and...
Diseases and injuries impose oxidative stress on different organs and systems of the body. This study was conducted to investigate the hepatoprotective effects of soy protein isolate against acute liver toxicity induced by dimethylnitrosamine (DMNA). Forty-eight Sprague Dawley rats were randomly divided into three groups. Groups A and B consumed a casein containing diet and the Group C received a soy protein isolate (SPI) containing diet for 18 days. Group A was then given an intra-peritoneal saline injection and continued on a casein diet for another 4 days before being killed. Each animal from groups B and C was given a single intra-peritoneal injection of DMNA (30 mg/ kg) on the 18th day of the study. All groups continued their diets for 4 days before their sacrifice. The serum ALT decreased and albumin increased significantly in rats fed 20 % SPI containing diet (P \ 0.05). Histological results showed that SPI improved DMNA-induced alteration in the liver structure. Morphological and biochemical data suggest that soy protein isolate containing diet decreased DMNA-induced liver damage.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.