Background: Obesity is abnormal accumulation of fat in the body, which led to many health problems that will reduce the life expectancy. Arthritis is joints inflammation that cause many of symptoms such as swelling, tenderness, pain and stiffness of most joints. The arthritis is divided into many types, but the most common types are osteoarthritis and rheumatoid arthritis the last type is the focus of our topic. Rheumatoid arthritis (RA) is an auto-immune, chronic inflammation that can cause damage for joints and other body organs like skin, eyes, lungs, heart and blood vessels.Objective: The study aimed to investigate the levels of leptin and estrogen hormones in obese women with arthritis. We focused on rheumatoid arthritis especially. Patients and Methods: The research included ninety women They were distributed into three groups, 30 obese women with body mass index (BMI) more than 25 Kg/m 2 for overweight and more than 30 Kg/m 2 for obese, 30 obese women with rheumatoid arthritis which have positive rheumatoid factor (RF) and 30 control women with normal weight and BMI < 25Kg/m 2 and healthy from RA. BMI, WHR was calculated for all participants. Result: The result of estrogen hormone showed highly significant difference (P≤0.01) in G1 (55. 74 ± 9.23), G2 (55.35 ± 11.77) compared to G3 (129.85 ±16.69). While leptin hormone revealed no significant difference among G1 (2102.13 ±78.03), G2 (2005.80 ±23.81) and G3 (1931.27 ±22.91). Conclusion:We concluded that leptin levels did not differ among the three groups. Conversely estrogen levels showed highly difference between the three groups.
Introduction and Aim: Obesity and overweight refers to excessive buildup of fat in the body. Arthritis is a group of medical disorders associated with obesity and being overweight. Obesity associated with rheumatoid arthritis is more pronounced in women. In this study, we aimed to evaluate some physiological and hematological parameters in obese women with arthritis. Materials and Methods: This study included 90 women aged between 18 and 68 years. The women were divided into three groups based on their BMI as Obese (n=30), Obese+RA (n=30) and normal lean women as controls (n=30). Blood drawn from each participant was tested for their complete blood tests, lipid profiles, C-reactive protein reaction and presence of rheumatoid factor. Data was subjected to statistical analysis. Results: Our study revealed the mean +SE for age, WHR and BMI to be elevated in women in the obese as well as Obese+RA groups and to be significantly higher in comparison to women in the control group. Except for HDL, all the other lipid parameters were seen elevated in the obese and Obese+RA group and showed significant difference from the control group. Similarly, among the complete blood count indices only ESR, WBC and PLT were found to be significantly elevated in obese and Obese+RA groups. The prevalence percentage for CRP and RF was seen to be highest in individuals belonging to the Obese+RA group. Conclusion: Obese women as well as obese women with RA have elevated hematological and physiological parameters when compared to lean women.
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