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AP have reduced exercise tolerance. There also appears to be a dose-related effect on myocardial contractility and SVI. These findings may help to guide treatment.

A novel method to obtain the aortic pressure waveform using a sequence of B-mode images is developed in this project. An automatic edge detection algorithm is applied to a sequence of longitudinal images of the aortic arch acquired from a suprasternal view. The aortic distension waveform is obtained by measuring the distance between the two edges throughout the cardiac cycle. It is then calibrated using the systolic and diastolic pressures from the brachial artery to obtain an estimated pressure waveform. This method was applied to 5 healthy children, pulse pressure amplification and total arterial compliance were calculated from the estimated waveforms.