The study showed that mucormycetes and other rare hyaline moulds exhibit variable susceptibilities to antifungals, and hence antifungal testing is valuable. The fact that the combination of amphotericin B with anidulafungin was found synergistic in some cases merits further investigation.

No abstract

No abstract

No abstract

The spread of active attacks has become a frequent cause of vast systems breakdown in modern communication networks. In this paper, we first present a probabilistic modeling framework for the propagation of an energy-constrained mobile threat in a wireless ad hoc network. The introduced formulation is used to identify and evaluate different attack strategies and approaches, which in turn can help in the development of efficient countermeasures for such attacks. Through modeling and simulation, we evaluate the impact of various parameters associated with the operational characteristics of the mobile attack nodesuch as transmission radius, mobility, energy -on an outbreak spreading and the evolution of the network. Furthermore, we introduce a new metric which indicates the overall infection-capability of each attack strategy and characterize their ability to harm the network according to this metric.

The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of two polymorphisms (4b/a and G894T) and their haplotypes in a case-control sample of 306 patients with BC and in 131 healthy females. In addition, a meta-analysis of studies investigating association between NOS3 polymorphisms and BC was conducted. The single locus analysis for the two polymorphisms revealed an association only for the 4b/a polymorphism, but adjustment for age diminished this association (odds ratio (OR) (95% confidence interval)¼0.98 (0.34-2.81)). The analysis of haplotypes showed an association for two haplotypes involving the 894T allele (bT and aT) (Po0.05). The meta-analysis for both polymorphisms produced nonsignificant associations without significant heterogeneity. A positive association was detected for the promoter T786C polymorphism (pooled OR¼1.51 (1.07-2.12)), but this comparison was based on few studies. The available evidence from our study and the meta-analysis cannot support a major contributory role of these common NOS3 polymorphisms in BC, although future larger studies may help in drawing safer conclusions about the genetics of BC.

Web Services (WS)

No abstract