The free energies of hydrolysis of ethyl acetate, methoxyethyl acetate, chloroethyl acetate, acetylcholine, and trifluoroethyl acetate to the free acid in aqueous solution at 25°( based on a water activity of 1.0) are -1660, -2180, -2840, -2940, and -4970 cal./mole, respectively. The equilibrium constants for acetyl transfer from acetylcholine to the thiol groups of N-acetyl-#3-mercaptoethylamine and mercaptoacetate are 0.076 and 0.132, respectively. The free energies of hydrolysis (to free acetic acid) of X,S-diacetyl-/3-mercaptoethy lamine and S-acetylmercaptoacetate are, therefore, -4460 and -4140 cal./mole, respectively, in good agreement with a previously reported value for a thiol ester of acetic acid.
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