This study examines the role of the media in sustaining regime stability in an authoritarian context. The article engages the recent work on authoritarian resilience in comparative politics but goes beyond the standard focus on elections to other important institutions, such as the media and courts, that are used by authoritarian leaders to bolster legitimacy. The authors find that the Chinese media contribute to regime legitimacy and effective rule by propagandizing citizens’ experiences in the legal system. However, unlike the “mouthpieces” of earlier communist regimes, the marketized Chinese media provide more convincing and sophisticated messages that continue to accord with state censorship demands while satisfying readers’ interest in real-life stories and problems. The “positive propaganda” and the relative uniformity of information sources because of state censorship lead aggrieved citizens to the law as a realm for dispute resolution and rights protection. Statistical analysis of a randomly sampled survey conducted in four Chinese cities in 2005 demonstrates that exposure to media reporting about labor-law-related issues successfully promotes the image of a proworker bias in the law among citizens, thus encouraging them to participate in the legal system. The state is able to achieve its political goal because of the lack of conflicting sources of information and the lack of previous experience with the reformed legal system among citizens.

This article critically examines the development of legal consciousness among legal aid plaintiffs in Shanghai. It is based on 16 months of research at a large legal aid center and in‐depth interviews with 50 plaintiffs. Chinese legal aid plaintiffs come to the legal process with high expectations about the possibility of protecting their rights; however, they also have only a vague and imprecise knowledge of legal procedure and their actual codified rights. Through this process of legal mobilization, plaintiffs' legal consciousness changes in two separate dimensions: changes in one's feelings of efficacy and competency vis‐à‐vis the law, and changes in one's perception/evaluation of the legal system. Put another way, the first dimension is “How well can I work the law?” and the second is “How well does the law work?” In this study I observe positive changes in feelings of individual efficacy and competency that are combined with more negative evaluations/perceptions of the legal system in terms of its fairness and effectiveness. The positive feelings of efficacy and voice provided by the legal process encourage labor dispute plaintiffs in the post‐dispute period to plan new lawsuits and to help friends and relatives with their legal problems. Disenchantment with the promises of the legal system does not lead to despondency, but to more critical, informed action. This study provides new evidence on the nature of China's developing legal system with a focus on the social response to the state‐led “rule of law” project.

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Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules. EMVs play important roles in various pathologies, including cancer and neurodegeneration. The regulation of EMV biogenesis is thus of great importance and novel ways for manipulating their release from cells have recently been highlighted. One of the pathways involved in EMV shedding is driven by peptidylarginine deiminase (PAD) mediated post-translational protein deimination, which is calcium-dependent and affects cytoskeletal rearrangement amongst other things. Increased PAD expression is observed in various cancers and neurodegeneration and may contribute to increased EMV shedding and disease progression. Here, we review the roles of PADs and EMVs in cancer and neurodegeneration.

Mucins are the principal components of mucus and mucin glycosylation has important roles in defence, microbial adhesion, immunomodulation, inflammation and cancer. Mucin expression and glycosylation are dynamic, responding to changes in local environment and disease. Potentially hundreds of heterogenous glycans can substitute one mucin molecule and it is difficult to identify biologically accessible glyco-epitopes. Thirty-seven mucins, from the reproductive and gastrointestinal (GI) tracts of six species (bovine, ovine, equine, porcine, chicken and deer) and from two human-derived cell lines, were purified. Following optimisation of mucin printing to construct a novel mucin microarray, the glycoprofiles of the whole mucins were compared using a panel of lectins and one antibody. Accessible glycomotifs of GI mucins varied according to species and localisation of mucin origin, with terminal fucose, the sialyl T-antigen and N-linked oligosaccharides identified as potentially important. The occurrence of T-and sialyl T-antigen varied in bovine and ovine reproductive tract mucins, and terminal N-acetylgalactosamine (GalNAc) and sulfated carbohydrates were detected. This study introduces natural mucin microarrays as an effective tool for profiling mucin glyco-epitopes and highlights their potential for discovery of biologically important motifs in bacterial-host interactions and fertility.

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f Helicobacter pylori and Campylobacter jejuni colonize the stomach and intestinal mucus, respectively. Using a combination of mucus-secreting cells, purified mucins, and a novel mucin microarray platform, we examined the interactions of these two organisms with mucus and mucins. H. pylori and C. jejuni bound to distinctly different mucins. C. jejuni displayed a striking tropism for chicken gastrointestinal mucins compared to mucins from other animals and preferentially bound mucins from specific avian intestinal sites (in order of descending preference: the large intestine, proximal small intestine, and cecum). H. pylori bound to a number of animal mucins, including porcine stomach mucin, but with less avidity than that of C. jejuni for chicken mucin. The strengths of interaction of various wild-type strains of H. pylori with different animal mucins were comparable, even though they did not all express the same adhesins. The production of mucus by HT29-MTX-E12 cells promoted higher levels of infection by C. jejuni and H. pylori than those for the non-mucus-producing parental cell lines. Both C. jejuni and H. pylori bound to HT29-MTX-E12 mucus, and while both organisms bound to glycosylated epitopes in the glycolipid fraction of the mucus, only C. jejuni bound to purified mucin. This study highlights the role of mucus in promoting bacterial infection and emphasizes the potential for even closely related bacteria to interact with mucus in different ways to establish successful infections.

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