The emerging histomorphologic features of our CTE cohort may specify histologic criteria for CTE diagnosis, may identify emerging histologic variants of CTE and may facilitate more objective surveillance and accurate identification of sentinel CTE cases.
ABSTRACT. Background. Prone sleep and unsafe sleep surfaces increase the risk of sudden infant death. Recent epidemiologic studies also suggest that when an infant's head or face is covered by bedding, or when a sleep surface is shared with others, the risk of dying increases. The inference of a causal role for these risk factors is supported by physiologic studies and by the consistent finding that fewer infants die when risk factors are reduced. The prevalence of most of these risk factors in infant deaths in the United States is uncertain.Objective. To describe the prevalence of several important risk factors related to sleep practices among a defined population of infants dying suddenly and unexpectedly.Methods. In this population-based study, we retrospectively reviewed death-scene information and medical examiners' investigations of deaths in the city of St Louis and St Louis County between January 1, 1994 and December 31, 1997. Because of the potential for diagnostic overlap, all deaths involving infants <2 years old with the diagnoses of sudden infant death syndrome (SIDS), accidental suffocation, or cause undetermined were included.Results. The deaths of 119 infants were studied. Their mean age was 109.3 days (range: 6 -350). The diagnoses were SIDS in 88 deaths, accidental suffocation in 16, and undetermined in 15. Infants were found prone in 61.1% of cases and were found on a sleep surface not designed for infants in 75.9%. The head or face was covered by bedding in 29.4%. A shared sleep surface was the site of death in 47.1%. Only 8.4% of deaths involved infants found nonprone and alone, with head and face uncovered.Conclusions. Using detailed death-scene descriptions, we found that similar unsafe sleeping practices occurred in the large majority of cases diagnosed as SIDS, accidental suffocation, and cause undetermined. Considering these diagnoses together may be useful in public health campaigns during a time when there may be diagnostic overlap. Regardless of the diagnosis, recommendations that infants sleep supine on firm sleep surfaces that lessen the risk of entrapment or head covering have the potential to save many lives. Campaigns are needed to heighten awareness of these messages and of the risks of dangerous bedsharing. Pediatrics 2000; 106(3). URL: http://www.pediatrics.org/cgi/content/full/ 106/3/e41; sudden infant death syndrome, sleep, child, consumer product safety, suffocation.ABBREVIATIONS. SIDS, sudden infant death syndrome; ME, medical examiner. E pidemiologic studies identifying risk factors and public health campaigns to reduce these risks have been followed by large reductions in the rates of sudden infant death syndrome (SIDS) in many countries. [1][2][3][4][5][6][7][8][9][10] In Reduce the Risk public health campaigns, priority has been given to risk factors that may be causally related to SIDS. 11,12 In addition, priority has been given to risk factors that are readily correctable and at the same time acceptable to care providers and parents.Many studies, including several r...
This article represents the work of the National Association of Medical Examiners Ad Hoc Committee on shaken baby syndrome. Abusive head injuries include injuries caused by shaking as well as impact to the head, either by directly striking the head or by causing the head to strike another object or surface. Because of anatomic and developmental differences in the brain and skull of the young child, the mechanisms and types of injuries that affect the head differ from those that affect the older child or adult. The mechanism of injury produced by inflicted head injuries in these children is most often rotational movement of the brain within the cranial cavity. Rotational movement of the brain damages the nervous system by creating shearing forces, which cause diffuse axonal injury with disruption of axons and tearing of bridging veins, which causes subdural and subarachnoid hemorrhages, and is very commonly associated with retinal schisis and hemorrhages. Recognition of this mechanism of injury may be helpful in severe acute rotational brain injuries because it facilitates understanding of such clinical features as the decrease in the level of consciousness and respiratory distress seen in these injured children. The pathologic findings of subdural hemorrhage, subarachnoid hemorrhage, and retinal hemorrhages are offered as "markers" to assist in the recognition of the presence of shearing brain injury in young children.
Disparate treatment: nursery school masculinely 2 result governed by teacher) or none Hopkins: impermissible sex stereotyping 3 Female Feminine Masculine (e.g., Act more Disparate impact: commission masculinely2 once employee shows salesperson) or that requiring masculine none or disfavoring feminine qualities has disparate impact on females, who are disproportionately feminine and not masculine, employer must then show that requiring masculine or disfavoring feminine characteristics is jobrelated and consistent with business necessity 4 Male Feminine Masculine Act more Ius tertii claim, raising masculinely2 argument made by feminine woman in row 3 above 5 Male Masculine Feminine (e.g., Act more Disparate impact: Jenny Craig femininely' analysis is mirror image counselor) of row 3 above Female Masculine Feminine Act more Analysis is mirror E _ II___femininely' image of row 4 above Notes: "'Act more femininely" is here a shorthand for, e.g., the advice given Ann Hopkins to "walk more femininely, talk more femininely, dress more femininely, wear make-up, have [your] hair styled .... wear jewelry" and go to "charm school." 490 U.S. at 235 (1989). 2 0r act less femininely. Both phrases are shorthand for the reverse of the advice given Hopkins, e.g., take off your makeup and jewelry, cut your hair short and go to assertiveness training class.
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