Social media postings are increasingly being used in modern days disaster management. Along with the textual information, the contexts and cues inherent in the images posted on social media play an important role in identifying appropriate emergency responses to a particular disaster. In this paper, we proposed a disaster taxonomy of emergency response and used the same taxonomy with an emergency response pipeline together with deep-learning-based image classification and object identification algorithms to automate the emergency response decision-making process. We used the card sorting method to validate the completeness and correctness of the disaster taxonomy. We also used VGG-16 and You Only Look Once (YOLO) algorithms to analyze disaster-related images and identify disaster types and relevant cues (such as objects that appeared in those images). Furthermore, using decision tables and applied analytic hierarchy processes (AHP), we aligned the intermediate outputs to map a disaster-related image into the disaster taxonomy and determine an appropriate type of emergency response for a given disaster. The proposed approach has been validated using Earthquake, Hurricane, and Typhoon as use cases. The results show that 96% of images were categorized correctly on disaster taxonomy using YOLOv4. The accuracy can be further improved using an incremental training approach. Due to the use of cloud-based deep learning algorithms in image analysis, our approach can potentially be useful to real-time crisis management. The algorithms along with the proposed emergency response pipeline can be further enhanced with other spatiotemporal features extracted from multimedia information posted on social media.
Social media platforms have proven to be effective for information gathering during emergency events caused by natural or human-made disasters. Emergency response authorities, law enforcement agencies, and the public can use this information to gain situational awareness and improve disaster response. In case of emergencies, rapid responses are needed to address victims' requests for help. The research community has developed many social media platforms and used them effectively for emergency response and coordination in the past. However, most of the present deployments of platforms in crisis management are not automated, and their operational success largely depends on experts who analyze the information manually and coordinate with relevant humanitarian agencies or law enforcement authorities to initiate emergency response operations. The seamless integration of automatically identifying types of urgent needs from millions of posts and delivery of relevant information to the appropriate agency for timely response has become essential. This research project aims to develop a generalized Information Technology (IT) solution for emergency response and disaster management by integrating social media data as its core component. In this paper, we focused on text analysis techniques which can help the emergency response authorities to filter through the sheer amount of information gathered automatically for supporting their relief efforts. More specifically, we applied state-of-the-art Natural Language Processing (NLP), Machine Learning (ML), and Deep Learning (DL) techniques ranging from unsupervised to supervised learning for an in-depth analysis of social media data for the purpose of extracting real-time information on a critical event to facilitate emergency response in a crisis. As a proof of concept, a case study on the COVID-19 pandemic on the
Introduction: Copy number variations (CNVs) play a critical role in the pathogenesis of neurodevelopmental disorders (NDD) among children. In this study, we aim to identify clinically relevant CNVs, genes and their phenotypic characteristics in an ethnically underrepresented homogenous population of Bangladesh.Methods: We have conducted chromosomal microarray analysis (CMA) for 212 NDD patients with male to female ratio of 2.2:1.0 to identify rare CNVs. To identify candidate genes within the rare CNVs, gene constraint metrics [i.e., “Critical-Exon Genes (CEGs)”] were applied to the population data. Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) was followed in a subset of 95 NDD patients to assess the severity of autism and all statistical tests were performed using the R package.Results: Of all the samples assayed, 12.26% (26/212) and 57.08% (121/212) patients carried pathogenic and variant of uncertain significance (VOUS) CNVs, respectively. While 2.83% (6/212) patients’ pathogenic CNVs were found to be located in the subtelomeric regions. Further burden test identified females are significant carriers of pathogenic CNVs compared to males (OR = 4.2; p = 0.0007). We have observed an increased number of Loss of heterozygosity (LOH) within cases with 23.85% (26/109) consanguineous parents. Our analyses on imprinting genes show, 36 LOH variants disrupting 69 unique imprinted genes and classified these variants as VOUS. ADOS-2 subset shows severe social communication deficit (p = 0.014) and overall ASD symptoms severity (p = 0.026) among the patients carrying duplication CNV compared to the CNV negative group. Candidate gene analysis identified 153 unique CEGs in pathogenic CNVs and 31 in VOUS. Of the unique genes, 18 genes were found to be in smaller (<1 MB) focal CNVs in our NDD cohort and we identified PSMC3 gene as a strong candidate gene for Autism Spectrum Disorder (ASD). Moreover, we hypothesized that KMT2B gene duplication might be associated with intellectual disability.Conclusion: Our results show the utility of CMA for precise genetic diagnosis and its integration into the diagnosis, therapy and management of NDD patients.
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