1,3,4-Oxadiazole scaffold is one of the most important heterocyclic fragments, which is considered as a perspective building block for drug discovery. Substituted 1,3,4-oxadiazoles had been reported to display a diverse range of pharmacological activities including anticancer, anti-inflammatory, antitubercular, antibacterial, antiviral, antifungal, insecticidal, antioxidant, and analgesic activities. Moreover, the 1,3,4-oxadiazole core is a structural component of approved antiretroviral (Raltegravir), anticancer (Zibotentan), and antihypertensive (Tiodazosin and Nesapidil) drugs. In the present review, we summarized the literature data about the main approaches for obtaining possible directions of structural modification and pharmacological activity of noncondensed heterocyclic systems based on the 1,3,4-oxadiazole ring as promising objects for modern bioorganic and medicinal chemistry.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.