Plant development is highly adaptable and controlled by a combination of various regulatory circuits that integrate internal and environmental cues. The phytohormone auxin mediates such growth responses, acting as a dynamic signal in the control of morphogenesis via coordinating the interplay between cell cycle progression and cell differentiation. Mutants in the chromatin-remodeling component
PROPORZ1
(PRZ1;
also known as
AtADA2b)
are impaired in auxin effects on morphogenesis, suggestive of an involvement of PRZ1-dependent control of chromatin architecture in the determination of hormone responses. Here we demonstrate that
PRZ1
is required for accurate histone acetylation at auxin-controlled loci. Specifically,
PRZ1
is involved in the modulation of histone modifications and corresponding adjustments in gene expression of
Arabidopsis KIP RELATED PROTEIN
(
KRP
) CDK inhibitor genes in response to auxin. Deregulated
KRP
expression in
KRP
silencer lines phenocopies
prz1
hyperproliferative growth phenotypes, whereas in a
KRP
overexpression background some mutant phenotypes are suppressed. Collectively, our findings support a model in which translation of positional signals into developmental cues involves adjustments in chromatin modifications that orchestrate auxin effects on cell proliferation.
Single gene silencing alters gene expression in both cycles and disrupts folate homeostasis. Folate over-supplementation and deficiency favors TS over MS cycle and causes prophase DNA damage.
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