Supplementary data are available at Bioinformatics online.

BackgroundA major obstacle to effectively treat and control tuberculosis is the absence of an accurate, rapid, and low-cost diagnostic tool. A new approach for the screening of patients for tuberculosis is the use of rapid diagnostic classification algorithms.MethodsWe tested a previously published diagnostic algorithm based on four biomarkers as a screening tool for tuberculosis in a Central European patient population using an assessor-blinded cross-sectional study design. In addition, we developed an improved diagnostic classification algorithm based on a study population at a tertiary hospital in Vienna, Austria, by supervised computational statistics.ResultsThe diagnostic accuracy of the previously published diagnostic algorithm for our patient population consisting of 206 patients was 54% (CI: 47%–61%). An improved model was constructed using inflammation parameters and clinical information. A diagnostic accuracy of 86% (CI: 80%–90%) was demonstrated by 10-fold cross validation. An alternative model relying solely on clinical parameters exhibited a diagnostic accuracy of 85% (CI: 79%–89%).ConclusionHere we show that a rapid diagnostic algorithm based on clinical parameters is only slightly improved by inclusion of inflammation markers in our cohort. Our results also emphasize the need for validation of new diagnostic algorithms in different settings and patient populations.

In the past decades recommender systems have become a powerful tool to improve personalization on the Web. Yet, many popular websites lack such functionality, its implementation usually requires certain technical skills, and, above all, its introduction is beyond the scope and control of end-users. To alleviate these problems, this paper presents a novel tool to empower end-users without programming skills, without any involvement of website providers, to embed personalized recommendations of items into arbitrary websites on client-side. For this we have developed a generic meta-model to capture recommender system configuration parameters in general as well as in a web augmentation context. Thereupon, we have implemented a wizard in the form of an easy-to-use browser plug-in, allowing the generation of so-called user scripts, which are executed in the browser to engage collaborative filtering functionality from a provided external rest service. We discuss functionality and limitations of the approach, and in a study with end-users we assess the usability and show its suitability for combining recommender systems with web augmentation techniques, aiming to empower end-users to implement controllable recommender applications for a more personalized browsing experience.

No abstract

No abstract