SARS‐CoV‐2 infection results in a mild‐to‐moderate disease course in most patients, allowing outpatient self‐care and quarantine. However, in ≈10% of cases a two‐ or three‐phasic critical disease course with starting from day 7 to 10 is observed. To facilitate and plan outpatient care, biomarkers prognosing such worsening at an early stage appear of outmost importance. In this accelerated article, the identification of urinary peptides significantly associated with SARS‐CoV‐2 infection, and the development of a multi‐marker urinary peptide based test, COVID20, that may enable prognosis of critical and fatal outcomes in COVID‐19 patients is reported. COVID20 is composed of 20 endogenous peptides mainly derived from various collagen chains that enable differentiating moderate or severe disease from critical state or death with 83% sensitivity at 100% specificity. Based on the performance in this pilot study, testing in a prospective study on 1000 patients has been initiated.
Conclusion:To retrieve results is a beneficial strategy to improve cleaning. To analyze data together with the staff allows finding out real and specific goals. Control is essential to sustain results through time.
Aufgrund der weltweit zunehmenden Mobilität gewinnen auch reiseassoziierte Erkrankungen
an Bedeutung. Lebensbedrohliche Infektionskrankheiten können schwer kontrollierbare
Ausbruchsituationen hervorrufen und stellen somit ein Risiko für das betreuende
medizinische Personal, aber auch für die Allgemeinbevölkerung dar. In Teil 1 geht es um
hämorrhagische Fiebererkrankungen sowie deren Infektionswege, Symptome und Behandlung.
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