Skins. -A three-step synthetic access towards enantioenriched trans-2,5-disubstituted pyrrolidines is presented. The sequence involves Ir-catalyzed highly regio-and enantioselective allylic amination, Suzuki-Miyaura cross coupling and diastereoselective intramolecular aza-Michael addition reactions. The so obtained pyrrolidines can be used for the preparation of a variety of pyrrolidine, pyrrolizidine and indolizidine alkaloids, e.g. indolizidine 223AB (IX). -(GAERTNER, M.; WEIHOFEN, R.; HELMCHEN*, G.; Chem. Eur. J. 17 (2011) 27, 7605-7622, http://dx.
Enantio-and Regioselective Iridium-Catalyzed Allylic Hydroxylation. -Branched allylic alcohols are prepared highly selectively using potassium bicarbonate as nucleophile and novel air-and water-stable Ir-catalysts. The method is applied to the carbonate (IV), prepared from natural brefeldin A. Alcohol (V) is obtained with high diastereoselectivity. -(GAERTNER, M.; MADER, S.; SEEHAFER, K.; HELMCHEN*, G.; J. Am. Chem. Soc. 133 (2011) 7, 2072-2075, http://dx.
Reactions of organo-metal compounds O 0350Five-and Six-Membered Nickelacyclic Carboxylates as Reagents for the Facile Synthesis of δ-Ketocarboxylic Acids, Isocoumarins, and 1,3-Dicarbonyl Derivatives of Benzoic Acid. -(to be continued). -(LANGER, J.; GAERTNER, M.; GOERLS, H.; WALTHER*, D.; Synthesis 2006, 16, 2697-2706; Inst. Anorg. Anal. Chem., Friedrich-Schiller-Univ., D-07743 Jena, Germany; Eng.) -Klein 51-048
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