Neuroblastoma (NB) is an embryonal tumor originating from the sympathetic nervous system, which occurs during fetal period or early postnatal period, and is one of the most common extracranial solid malignant tumors in children. Cytokines are pleiotropic proteins that can effectively activate tumor immune cells and counteract immune suppression, thereby suppressing tumors. Cytokine immunotherapy provides more possibilities for the application of immunotherapy through its own induction and activation of the immune system and has also been extensively studied in NB immunotherapy. This article mainly introduces the research progress of several immunotherapies based on cytokines in the treatment of children with NB.