Tumour-specific hTR expression confirms hTR inhibition as a possible therapeutic strategy in some if not all oesophageal and oral cancers. Generally concordant hTR status between biopsy and resection suggest that biopsy may have a role in selecting candidates for telomerase inhibition therapy.

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4 Almoudaris AM, Burns EM, Bottle A, Aylin P, Darzi A, Faiz O. A colorectal perspective on voluntary submission of outcome data to clinical registries. Br J Surg 2011; 98: 132-9. 5 Raftery J, Roderick P, Stevens A. Potential use of routine databases in health technology assessment. Heal Technol Assess 2005; 9: 1-92.We would like to thank Dr Dahlia AA Hawezy and Robyn Boyle who designed and drawn diagram of the procedure.

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